He began his career in the Singapore Police Force in 1977, after a short stint in the Singapore Armed Forces and was its Commissioner from 1997 to 2010. He also served as President of INTERPOL from 2008 to 2012. After his stint in the Police, Mr Khoo was appointed the Senior Deputy Secretary of the Ministry of Home Affairs from 2010 to 2014. He concurrently assumed the appointment of Director of the Institute of Leadership and Organisation Development, Civil Service College in 2013. Upon his retirement from the Government, Mr Khoo was appointed the Senior Advisor of the Ministry of Home Affairs in 2015 on contract, and a year later was re-designated a Senior Fellow. He is also a Senior Fellow of the Civil Service College and the Home Team Academy.
He is Chairman of the Singapore Island Country Club, the Singapore Golf Association Governing Council, the Deputy Chairman of the Singapore Quality Award Governing Council and also a board member of Singapore Technologies Engineering Ltd, Singapore Health Services Pte Ltd, Ministry of Health Holdings, Casino Regulatory Authority of Singapore and Temasek Foundation.
He is an Advisor to INTERPOL, Singapore’s National Cybersecurity R&D Programme, Standard Chartered Bank UK’s Board Financial Crime Risk Committee, Palo Alto Networks’ Public Sector Council and Oxford University’s Journal of Police. He co-chairs the annual US Singapore Law Enforcement Homeland Security and Safety Co-operation Dialogue with his counterparts from the US Department of Justice and Homeland Security, and is a member of the Global Initiative against Transnational Organised Crime. He was Chairman of Technology Against Crime, the organiser of the International Forum on Technologies for a Safer World, based in France and is the Conference Chairman of Milipol Asia Pacific; and also served on the Independent Commission on the Future of UK Policing, as well as the World Economic Forum Meta-Council on the Illicit Economy. He also chaired the first two ASEAN Senior Officials’ Roundtable on Cybercrime and co-chaired the Singapore Safe City testbed initiative.